Mounjaro, alternatively known as Zepbound in the US, is an innovative prescription therapy designed to aid weight loss when complemented with a calorie-restricted diet and consistent physical activity.
Originally developed for treating type 2 diabetes, Mounjaro has received recent approval from the Medicines and Health Regulatory Agency (MHRA) for assisting weight loss and weight management in adults aged 18 and older.
Mounjaro features tirzepatide as its active component, distinguishing itself as the initial medication to mimic the effects of two distinct hormones capable of decreasing food cravings, appetite, and blood sugar levels.
By prolonging stomach emptying time, Mounjaro facilitates a prolonged sensation of fullness, aiding in weight loss efforts. Moreover, it influences brain regions responsible for appetite and hunger control, promoting a feeling of satiety even with reduced food intake.
Numerous studies were conducted to evaluate Mounjaro's efficacy as a weight loss therapy. Subsequent to these investigations, Mounjaro received approval in the UK for weight loss.
The SURMOUNT-1 clinical trial revealed that 85.1% of individuals utilizing tirzepatide on a weekly basis experienced a minimum 5% reduction in their initial body weight over a 72- week period. Notably, higher dosage levels correlated with more substantial weight loss outcomes, as illustrated below:
Average weight loss (the percentage of weight lost compared to starting body weight)
For weight loss with Mounjaro, it is recommended to administer the injection once a week, consistently on the same day and at the same time. This practice aids in maintaining steady tirzepatide levels in the bloodstream, minimizing the potential for side effects and enhancing overall effectiveness.
Mounjaro is best injected into either the upper thighs or the abdomen. When opting for the abdominal area, ensure a minimum 5cm distance from the belly button. Since Mounjaro is administered only once weekly, the likelihood of experiencing significant soreness or irritation at the injection site is minimal. Nevertheless, to mitigate any potential discomfort, it's advisable to rotate injection sites weekly, even if it means selecting a different area within the same region of the skin.
If you're currently taking Saxenda or Wegovy, it's necessary to wait for a month before transitioning to Mounjaro. This interval, known as the 'washout' period, allows the body time to eliminate the previous medication from the system. Upon initiating Mounjaro, all patients will commence with a 2.5mg dosage.
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